Global challenges require cross-border collaboration. Viruses have no respect for territorial boundaries, and the subsequent economic, social, and political challenges can have both domestic and international consequences. While health care workers are on the front lines to help reduce the loss of life and human suffering caused by the COVID-19 pandemic, diverse stakeholders are actively thinking about how to move from the crisis phase to stabilization and reconstruction. One key challenge faced by the international community is how to reinforce multilateral cooperation to reduce the risk of future epidemics. This policy brief highlights the challenges associated with multilateralism and recommends some policy measures that the G20 should take to facilitate enhanced collaboration on global problems.